4H-Pyrido[3,2-b][1,4]oxazin-3-one

4H-Pyrido[3,2-b][1,4]oxazin-3-one - Names and Identifiers

Name	2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one
Synonyms	TIMTEC-BB SBB006815 LABOTEST-BB LT00451615 4H-Pyrido[3,2-b][1,4]oxazin-3-one 4H-pyrido[2,3-e][1,4]oxazin-3-one 2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one 2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one 2H-PYRIDO[3,2-B]-1,4-OXAZIN-3(4H)-ONE 2,3-dihydro-3-oxo-4H-pyrido[3,2-b]-1,4-oxazine 3,4-Dihydro-2H-pyrido[3,2-b]-1,4-oxazine-3-one
CAS	20348-09-8
EINECS	243-751-1
InChI	InChI=1/C7H6N2O2/c10-6-4-11-5-2-1-3-8-7(5)9-6/h1-3H,4H2,(H,8,9,10)

4H-Pyrido[3,2-b][1,4]oxazin-3-one - Physico-chemical Properties

Molecular Formula	C7H6N2O2
Molar Mass	150.13
Density	1.327±0.06 g/cm3(Predicted)
Melting Point	204-206°C(lit.)
Boling Point	384.2±37.0 °C(Predicted)
Flash Point	186.133°C
Vapor Presure	0mmHg at 25°C
BRN	1074010
pKa	11.06±0.20(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.568

4H-Pyrido[3,2-b][1,4]oxazin-3-one - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
Hazard Class	IRRITANT

4H-Pyrido[3,2-b][1,4]oxazin-3-one - Reference Information

application

pyridine oxazine is a kind of secondary metabolites widely existing in gramineous plants. it has broad-spectrum disease resistance and insect resistance, can act on a variety of crop diseases and insect pests, and is also a resistance index for crop breeding. This kind of chemical substance is represented by Dingbu, which is an important compound for studying the relationship between insects and plants.

preparation

due to the special biological activity of pyridine oxazine compounds, the synthesis of such compounds has been widely concerned. the commonly used method for synthesizing pyridine [3,2-b][1,4] oxazine compounds in the literature is prepared by Mannich reaction with phenol, primary amine and aldehyde as raw materials. Another more important method is to use o-aminomethylphenol and aldehydes or ketones to shrink into rings under the catalysis of SnCl4, Me,SiCl, etc. In this paper, the target compound 2H-pyridine [3,2-b][1,4] oxazin-3 (4H)-one [1] was prepared by ring-closing reaction with 2-amino-3-hydroxypyridine and chloroacetic acid as starting materials. The synthesis reaction formula of 2H-pyridino [3,2-b][1,4] oxazine -3(4H)-one is as follows:

Last Update：2024-04-09 18:58:34